Phenotypes Associated with This Genotype

Genotype
MGI:5906027

• Allelic Composition: Dhfr^orana/Dhfr^orana
• Genetic Background: involves: C57BL/6JAnu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:236197 )

• mice die soon after E14.5

hematopoietic system

decreased common myeloid progenitor cell number ( J:236197 )

• at E11.5 and E13.5

decreased granulocyte monocyte progenitor cell number ( J:236197 )

• at E11.5

decreased erythroid progenitor cell number ( J:236197 )

• at E11.5 and E13.5

decreased erythrocyte cell number ( J:236197 )

• in the livers at E11.5 and E13.5

increased nucleated erythrocyte cell number ( J:236197 )

growth/size/body

decreased embryo size ( J:236197 )

• at E13.5

decreased fetal size ( J:236197 )

• at E14.5

liver/biliary system

liver hypoplasia ( J:236197 )

• at E11.5 and E13.5

pale liver ( J:236197 )

• slightly at E11.5

homeostasis/metabolism

abnormal folic acid level ( J:236197 )

• less than half of folate in whole embryo at E13.5

• 9-fold lower 5,6,7,8-tetrahydrofolate (THF) in whole embryo at E13.5

• 15-fold higher folic acid levels in whole embryo at E13.5

• reduced total folate, 5-methyl THF and THF concentrations in E13.5 livers

integument

pallor ( J:236197 )

• at E13.5 and E14.5

cellular

abnormal DNA methylation ( J:236197 )

• small increase in average methylation across Kcnq1ot1 CpG island

embryo

decreased embryo size ( J:236197 )

• at E13.5