Phenotypes Associated with This Genotype

Genotype
MGI:5905986

• Allelic Composition: Wnt10a^tm1.1Smr/Wnt10a^tm1.1Smr
• Genetic Background: involves: 129X1/SvJ * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal alveolar process morphology ( J:242196 )

• decreased alveolar bone density by 1 year age

abnormal molar morphology ( J:242196 )

• flattened cusps and reduced size as early as E17.5

• however, non-dental epithelia develops normally

abnormal molar cusp morphology ( J:242196 )

• flattened cusps as early as E17.5

abnormal molar root morphology ( J:242196 )

• defective root bifurcation and extension

absent molars ( J:242196 )

• frequently missing molar teeth

small molars ( J:242196 )

• as early as E17.5

supernumerary molars ( J:242196 )

• half of mice develop loosely anchored ectopic molar M4 teeth

abnormal tongue morphology ( J:242196 )

• flattened surface

abnormal filiform papillae morphology ( J:242196 )

• progressive from P7

abnormal fungiform papillae morphology ( J:242196 )

• progressive from P7

abnormal gustatory papilla taste bud morphology ( J:242196 )

• miniaturized

integument

abnormal sweat gland morphology ( J:242196 )

• fail to extend

abnormal nail morphology ( J:242196 )

• defective nail growth in some mice

taste/olfaction

taste/olfaction phenotype ( J:242196 )

N • mice exhibit normal taste response to sweet, sour, salt or bitter tastes, or for the irritant, capsaicin

abnormal gustatory papilla taste bud morphology ( J:242196 )

• miniaturized

behavior/neurological

increased fluid intake ( J:242196 )

• following mild, but not severe, water restriction

skeleton

abnormal alveolar process morphology ( J:242196 )

• decreased alveolar bone density by 1 year age

abnormal molar morphology ( J:242196 )

• flattened cusps and reduced size as early as E17.5

• however, non-dental epithelia develops normally

abnormal molar cusp morphology ( J:242196 )

• flattened cusps as early as E17.5

abnormal molar root morphology ( J:242196 )

• defective root bifurcation and extension

absent molars ( J:242196 )

• frequently missing molar teeth

small molars ( J:242196 )

• as early as E17.5

supernumerary molars ( J:242196 )

• half of mice develop loosely anchored ectopic molar M4 teeth

growth/size/body

abnormal alveolar process morphology ( J:242196 )

• decreased alveolar bone density by 1 year age

abnormal molar morphology ( J:242196 )

• flattened cusps and reduced size as early as E17.5

• however, non-dental epithelia develops normally

abnormal molar cusp morphology ( J:242196 )

• flattened cusps as early as E17.5

abnormal molar root morphology ( J:242196 )

• defective root bifurcation and extension

absent molars ( J:242196 )

• frequently missing molar teeth

small molars ( J:242196 )

• as early as E17.5

supernumerary molars ( J:242196 )

• half of mice develop loosely anchored ectopic molar M4 teeth

abnormal tongue morphology ( J:242196 )

• flattened surface

abnormal filiform papillae morphology ( J:242196 )

• progressive from P7

abnormal fungiform papillae morphology ( J:242196 )

• progressive from P7

abnormal gustatory papilla taste bud morphology ( J:242196 )

• miniaturized

digestive/alimentary system

abnormal tongue morphology ( J:242196 )

• flattened surface

abnormal filiform papillae morphology ( J:242196 )

• progressive from P7

abnormal fungiform papillae morphology ( J:242196 )

• progressive from P7

abnormal gustatory papilla taste bud morphology ( J:242196 )

• miniaturized

endocrine/exocrine glands

abnormal sweat gland morphology ( J:242196 )

• fail to extend