Phenotypes Associated with This Genotype

Genotype
MGI:5904837

• Allelic Composition: Clcn7^tm2.1Mjec/Clcn7^tm2.1Mjec
• Genetic Background: 129(Cg)-Clcn7^tm2.1Mjec

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased bone mineral content ( J:240468 )

• +13% m, unchanged f at 3 months normalized for body weight

• +28% m, +10% f at 6 months normalized for body weight

increased areal bone mineral density ( J:240468 )

• slightly (+5% m, +2% f) at 3 months

• +17% m, +3% f at 6 months

increased trabecular bone volume ( J:240468 )

• +106% m, +96% f at distal femur at 3 months

• +700% m, +400% f at distal femur at 6 months

increased bone trabecula number ( J:240468 )

• +32% m, +27% f at distal femur at 3 months

• +69% m, +29% f at distal femur at 6 months

increased trabecular bone thickness ( J:240468 )

• +13% m, +20% f at distal femur at 3 months

• +65% m, +51% f at distal femur at 6 months

growth/size/body

decreased body weight ( J:240468 )

• slightly (-7% m, -2% f) at 3 months