Analysis Tools
immune system
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• mice challenged with house dust mite extract show improved lung function, attenuated airway hyperresponsiveness and mucus secretion, decrease in blood and bronchioalveolar lavage fluid eosinophils, a decrease in lung IL13 levels and collagen levels, decrease in smooth muscle thickness and depletion of goblet cell metaplasia compared to controls
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mortality/aging
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• tamoxifen treated mice treated with bleomycin to induce lung damage at 6 weeks of age show increased survival (79%) compared to controls (33%)
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homeostasis/metabolism
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• house dust mite-induced increase in airway collagen content is reduced in tamoxifen treated mice
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• tamoxifen treated mice treated with bleomycin to induce lung damage at 6 weeks of age show increased survival (79%) compared to controls (33%)
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• tamoxifen treated mice show protection against lung vascular fragility and permeability, reduced inflammatory cell presence in bronchioalveolar lavage fluid, reduced proliferation in lung perivascular areas and the alveolar parenchyma, reduced alveolar damage, and attenuation of acute lung inflammation and bone marrow neutrophilopoiesis after bleomycin-induced lung damage
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respiratory system
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• house dust mite-induced goblet cell hyperplasia is reduced in tamoxifen treated mice
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• house dust mite-induced airway hyperresponsiveness is attenuated in tamoxifen treated mice
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