Phenotypes Associated with This Genotype

Genotype
MGI:5903251

• Allelic Composition: Grk1^tvrm207/Grk1^tvrm207
• Genetic Background: B6.Cg-Grk1^tvrm207/Pjn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

retina photoreceptor degeneration ( J:241495 )

• althought the outer nuclear layer has only a small reduction in thickness at 3 months of age, by 12 months of age photoreceptors are absent

decreased total retina thickness ( J:241495 )

retina spots ( J:241495 )

• fundus photography at one year of age shows retinal spotting and a granular appearance

abnormal electroretinogram waveform feature ( J:241495 )

• both dark-adapted and light-adapted ERGs have a significantly reduced amplitude as early as 19 days of age with little progression up to 4 months of age, the latest time point assessed

nervous system

retina photoreceptor degeneration ( J:241495 )

• althought the outer nuclear layer has only a small reduction in thickness at 3 months of age, by 12 months of age photoreceptors are absent