Analysis Tools
immune system
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• mice exhibit normal secondary lymphoid tissue formation
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• impaired chemotaxis toward CXCL13 in conventional dendritic cell
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• marginal reduction in the follicle dendritic cells in the spleen
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• following oral administration of scrapie prion proteins, mice exhibit reduced follicular dendritic cell-associated accumulation of prion protein in the spleen compared with control mice
• splenectomy before oral prion exposure does not alter susceptibility
• however, prion disease susceptibility is normal when infection is established directly within the CNS
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cellular
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• impaired chemotaxis toward CXCL13 in conventional dendritic cell
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hematopoietic system
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• impaired chemotaxis toward CXCL13 in conventional dendritic cell
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