Phenotypes Associated with This Genotype

Genotype
MGI:5902743

• Allelic Composition: Zg16^tm1Lex/Zg16^tm1Lex
• Genetic Background: B6.129S-Zg16^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased circulating interferon-gamma level ( J:239095 )

increased circulating interleukin-6 level ( J:239095 )

• in mice maintained with wild-type mice and those bred separately from several generations

increased susceptibility to bacterial infection ( J:239095 )

• mice exhibit increased bacterial loads of gram positive bacteria in draining caudal lymph nodes and spleen compared with wild-type mice

• however, treatment with a broad-spectrum antibiotic lowers intestinal bacterial load

digestive/alimentary system

abnormal intestine morphology ( J:239095 )

• mice exhibit increased bacterial penetration of gram positive bacteria into inner mucus layer of the colon compared with wild-type mice

• however, inner mucus layer thickness is normal

growth/size/body

increased body weight ( J:239095 )

• in mice bred separately for several generations from wild-type mice

adipose tissue

increased abdominal fat pad weight ( J:239095 )

• however, treatment with a broad-spectrum antibiotics reverts fat pad mass

homeostasis/metabolism

increased circulating interferon-gamma level ( J:239095 )

increased circulating interleukin-6 level ( J:239095 )

• in mice maintained with wild-type mice and those bred separately from several generations