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Phenotypes Associated with This Genotype
Genotype
MGI:5902399
Allelic
Composition		 Agtr1atm3Tma/Agtr1atm3Tma
Tg(Nphs1-cre)10Mska/0
Tg(Nphs1-IL2RA)18Mska/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm3Tma mutation (0 available); any Agtr1a mutation (38 available)
Tg(Nphs1-cre)10Mska mutation (0 available)
Tg(Nphs1-IL2RA)18Mska mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:240316 )
N
• mice do not show proteinuria and renal morphology is normal
• mice injected with an immunotoxin, anti-Tac(Fv)-PE38 (LMB2) develop the same level of glomerulosclerosis as controls
• mice injected with LMB2 to induce glomerular injury that are treated with angiotensin II type 1 receptor blocker (ARB) show attenuation of glomerulosclerosis progression

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory