Phenotypes for Ola1 MGI:5898261 MGI Mouse

neonatal lethality, incomplete penetrance ( J:236306 )

• 80% of mice die within 24h of birth but are present at expected numbers at E18.5

• however, a small proportion of mice survive to adulthood

• from E16.5-E18.5 lung development is delayed by1.0 day compared to controls

• no signs of catch-up in lung development are seen between E18.5 and P0 suggesting that lung immaturity may contribute to neonatal death and respiratory distress

abnormal branching involved in lung morphogenesis ( J:236306 )

• at E15.5 lungs show fewer and larger epithelial tubes and lungs have a more sponge-like appearance

respiratory distress ( J:236306 )

• at P0, probably due to immature lungs

cyanosis ( J:236306 )

• pups that die are cyanotic

delayed hepatic development ( J:236306 )

• delay in hepatic hematopoiesis with fewer hematopoietic cells present at E13.5 and a delay in the normal decline in hematopoietic cells so that at E16.5 the liver is still dominated by hematopoietic cells

• red cells in livers retain their nuclei unlike in wild-type controls

• at P0 liver development continues to appear delayed with an increase in the number of hematopoietic cells and poor formation of hepatic cords

reproductive system phenotype ( J:236306 )

N	• surviving mice are fertile

embryonic growth retardation ( J:236306 )

• development appears to be delayed by 0.75 to 1.0 days

decreased embryo size ( J:236306 )

• from E8.5 onward

decreased birth body size ( J:236306 )

• all dead pups are smaller than wild-type or heterozygous littermate controls

decreased body size ( J:236306 )

• surviving mice are smaller at weaning and as adults

decreased body weight ( J:236306 )

• at weaning average body weight is about half that of wild-type controls

• at 19 weeks of age average body weight of males and females is 65% and 72% of their gender-matched wild-type controls

decreased body length ( J:236306 )

• at 19 weeks of age, body length is about 90% of wild-type controls

decreased fetal weight ( J:236306 )

• body weight is decreased by 35% at E18.5

abnormal definitive hematopoiesis ( J:236306 )