Phenotypes Associated with This Genotype

Genotype
MGI:5898089

• Allelic Composition: Gkn2^{tm1.1(KOMP)Vlcg}/Gkn2^{tm1.1(KOMP)Vlcg}; Il6st^tm1Ern/Il6st^tm1Ern
• Genetic Background: involves: 129S1/Sv * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal stomach mucosa morphology ( J:234656 )

• corpus tumors display poorly differentiated and hyperplastic epithelium histologically

increased stomach mucosa thickness ( J:234656 )

• in the corpus mucosa as a result of tumor formation

• however, antral mucosa thickness is similar to Il6st single mutants

increased stomach tumor incidence ( J:234656 )

• unlike Il6st single mutants which develop primarily antral tumors, double mutants show extensive focal tumorigenesis of the corpus and squamous epithelium overlying the limiting ridge of the corpus/forestomach junction at 12 weeks of age

• increase in both the number of corpus tumor foci and macroscopic corpus tumor area

• however, antral tumor load is similar to Il6st single mutants

neoplasm

increased stomach tumor incidence ( J:234656 )

• unlike Il6st single mutants which develop primarily antral tumors, double mutants show extensive focal tumorigenesis of the corpus and squamous epithelium overlying the limiting ridge of the corpus/forestomach junction at 12 weeks of age

• increase in both the number of corpus tumor foci and macroscopic corpus tumor area

• however, antral tumor load is similar to Il6st single mutants