Phenotypes for Apc Elp3 Lgr5 MGI:5898005 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Elp3^tm1.1Tac/Elp3^tm1.1Tac Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (5 available); any Apc mutation (156 available)
Elp3^tm1.1Tac mutation (0 available); any Elp3 mutation (40 available)
Lgr5^{tm1(cre/ERT2)Cle} mutation (1 available); any Lgr5 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:227334 )

• the amount of Dclk1+/Sox9+ cells in the Lgr5+ population is decreased in ex vivo organoids

abnormal small intestinal crypt cell physiology ( J:227334 )

• intestinal crypts fail to efficiently generate spheroid structures ex vivo

neoplasm

decreased tumor growth/size ( J:227334 )

• tamoxifen treated mice exhibit decreased numbers of hyperplastic foci/polyps in the intestine indicating impaired tumor initiation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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