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Phenotypes Associated with This Genotype
Genotype
MGI:5897776
Allelic
Composition
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Tg(TPO-cre)1Shk/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm1.2Lsk mutation (1 available); any Prkar1a mutation (16 available)
Tg(TPO-cre)1Shk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• thyroids show increased cellularity but retain a follicular pattern of growth
• 100% of mice exhibit enlargement of the thyroid
• thyroids exhibit locally invasive follicular thyroid carcinoma (J:225245)
• tumors exhibit high proliferation rate (J:225245)
• mice develop follicular thyroid carcinoma at a rate of 43% by one year of age (J:241066)
• tumors exhibit increased proliferation compared to wild-type thyroid glands (J:241066)
• however, none of the tumors show widely invasive or angio-invasive behavior (J:241066)
• mice are hyperthyroid

homeostasis/metabolism
• TSH levels are lower but not statistically significant due to wide variation in wild-type mice
• T4 levels are elevated, indicating hyperthyroidism

neoplasm
• thyroids exhibit locally invasive follicular thyroid carcinoma (J:225245)
• tumors exhibit high proliferation rate (J:225245)
• mice develop follicular thyroid carcinoma at a rate of 43% by one year of age (J:241066)
• tumors exhibit increased proliferation compared to wild-type thyroid glands (J:241066)
• however, none of the tumors show widely invasive or angio-invasive behavior (J:241066)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
thyroid gland follicular carcinoma DOID:3962 OMIM:188470
J:241066


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory