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Phenotypes Associated with This Genotype
Genotype
MGI:5897675
Allelic
Composition
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(TPO-cre)1Shk/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm1.2Lsk mutation (1 available); any Prkar1a mutation (16 available)
Ptentm1.1Mwst mutation (0 available); any Pten mutation (78 available)
Tg(TPO-cre)1Shk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival age of 6 months

growth/size/body
• males exhibit lower body weight beginning at 1 month of age which becomes statistically significant at 5 months of age

endocrine/exocrine glands
• 100% of mice develop follicular thyroid carcinoma by 8 weeks of age, showing capsular and/or vascular invasion
• tumors show a molecular signature similar to human sporadic follicular thyroid cancer
• mice are hyperthyroid

adipose tissue
• reduction in subcutaneous adipose tissue
• reduction in visceral adipose tissue

homeostasis/metabolism
• free T4 levels are increased

integument
• reduction in subcutaneous adipose tissue

neoplasm
• 100% of mice develop follicular thyroid carcinoma by 8 weeks of age, showing capsular and/or vascular invasion
• tumors show a molecular signature similar to human sporadic follicular thyroid cancer
• metastatic follicular thyroid carcinoma is seen in the lungs of 27% of mice; metastases are well differentiated, maintain follicular structure with colloid, and stain for thyroglobulin
• tumors exhibit only mild increases in proliferation rate compared to those in single homozygous Prkar1atm1.2Lsk Tg(TPO-cre)1Shk/0 mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
thyroid gland follicular carcinoma DOID:3962 OMIM:188470
J:241066


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory