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Phenotypes Associated with This Genotype
Genotype
MGI:5897419
Allelic
Composition		 Adatm1Mw/Adatm1Mw
Adora2btm1Dgen/Adora2btm1Dgen
Tg(Afp-ADA)#Xiay/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adatm1Mw mutation (3 available); any Ada mutation (31 available)
Adora2btm1Dgen mutation (0 available); any Adora2b mutation (19 available)
Tg(Afp-ADA)#Xiay mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:234143 )
N
• preeclampsia features seen in Adatm1Mw/Adatm1Mw Tg(Afp-ADA)#Xiay/0 dams, including hypertension are ameliorated

renal/urinary system
renal/urinary system phenotype ( J:234143 )
N
• preeclampsia features seen in Adatm1Mw/Adatm1Mw Tg(Afp-ADA)#Xiay/0 dams dams, including proteinuria and renal changes are ameliorated

embryo
abnormal placenta morphology ( J:234143 )
• mice exhibit an increase in placental adenosine levels
• however, placental weight is increased and placental vasculature is more organized and uniform compared to Adatm1Mw/Adatm1Mw Tg(Afp-ADA)#Xiay/0 mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory