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Phenotypes Associated with This Genotype
Genotype
MGI:5897270
Allelic
Composition
Lbric-J/Lbr+
Genetic
Background
(NZW/LacJ x C57BL/6J-Lbric-J/J)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbric-J mutation (1 available); any Lbr mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• neutrophils of both males and females show alternations in nuclear morphology
• females, but not males, show splenomegaly at 9 months of age

immune system
• neutrophils of both males and females show alternations in nuclear morphology
• females, but not males, show splenomegaly at 9 months of age
• females develop lupus autoimmunity, with induction of several autoantibodies, including anti-modified histones, IgG2 antibodies recognizing chromatin, and IgM directed against calreticulin, kidney damage and splenomegaly
• females show development of autoimmunity directed against components of the A-type lamina, but not lamin A/C itself
• anti-neutrophil autoreactivity mediated by IgM is directed against calreticulin, but not myeloperoxidase or proteinase 3, with 9 of 11 females showing detectable anti-calreticulin IgM titers
• females exhibit an increase in serum anti-nuclear antibody levels
• females develop an anti-nuclear autoimmune response that selectively recognizes specific modified histones
• females exhibit an increase in serum titers of anti-chromatin antibodies
• IgG2a, IgG2b, IgG2c, and IgM are prevalent anti-chromatin immunoglobulin subtypes in sera
• however, distribution of anti-double stranded DNA does not differ from controls

renal/urinary system
• females, but not males, develop kidney damage, with formation of inflammatory foci
• females show glomerular deposition of immune complexes
• females exhibit moderate-to-severe glomerulosclerosis and tubulointerstitial fibrosis with perivascular infiltration of mononuclear cells
• females exhibit moderate-to-severe tubulointerstitial fibrosis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory