Phenotypes Associated with This Genotype

Genotype
MGI:5896978

• Allelic Composition: Otud6b^{tm1b(EUCOMM)Wtsi}/Otud6b^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Otud6b^{tm1b(EUCOMM)Wtsi}
• Cell Lines: EPD0016_2_H08

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:240669 )

• homozygotes die between E18.5 and shortly after birth

growth/size/body

decreased fetal size ( J:240669 )

• microcomputed tomography revealed that fetuses are smaller than normal at E18.5; however, the 34% reduction in embryo volume is not significant

cardiovascular system

ventricular septal defect ( J:240669 )

• ventricular septal defects (VSDs) are detected in 80% of mutant hearts (3 of 3 hearts at E14.5 and 1 of 2 hearts at E18.5) relative to 0.67% in wild-type hearts