Phenotypes Associated with This Genotype

Genotype
MGI:5896837

• Allelic Composition: Tg(Thy1-UBQLN2)356Mont/0
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:239510 )

N • memory performance is similar to wild-type in novel object recognition test

N • mice do not exhibit evidence of motor difficulties

N • mice do not differ from wild-type in rotarod performance or forelimb/hindlimb grip strength

growth/size/body

growth/size/body region phenotype ( J:239510 )

N • mice do not differ from wild-type in body weight

mortality/aging

mortality/aging ( J:239510 )

N • survival is similar to wild-type

nervous system

nervous system phenotype ( J:239510 )

N • number of inclusions is similar to wild-type

astrocytosis ( J:239510 )

• minimal astrocytosis is observed in 8 month old, but not 1, month old mice

loss of hippocampal neurons ( J:239510 )

• neuronal loss is observed in the dentate gyrus at both 3 and 8 months

• no loss is observed in the CA1 region

decreased motor neuron number ( J:239510 )

• loss of corticospinal neurons at 3 and 8 months of age

• no lower motor neuron loss observed

abnormal axon morphology ( J:239510 )

• increase in number of small-caliber axons as compared to large-caliber axons in gastrocnemius muscle, however, overall number of large-caliber axons is unchanged

cellular

astrocytosis ( J:239510 )

• minimal astrocytosis is observed in 8 month old, but not 1, month old mice