Phenotypes Associated with This Genotype

Genotype
MGI:5896610

• Allelic Composition: C1ql1^tm1.1Yuza/C1ql1^tm1.1Yuza
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:219706 )

N • normal cerebellar foliation and lamination of cortical structures

abnormal neuron morphology ( J:219706 )

• reduced number of vGluT2+ puncta in the cerebella

• climbing fiber terminals penetrate to a shallower depth than in wild-type mice

abnormal afterhyperpolarization ( J:219706 )

• reduced complex spikes from Purkinje cells

• reduced climbing fiber-evoked afterhyperpolarization and suppression of spontaneous spikes

abnormal single cell response ( J:219706 )

• whole-cell patch-clamp recordings show reduced one-to-one relationship of Purkinje cells with climbing fibers and smaller amplitude of strongest climbing fiber excitatory postsynaptic currents

absent long-term depression ( J:219706 )

• simultaneously activating parallel fibers and climbing fibers for 2 min at 1 Hz in the current-clamp mode fails to develop long term depression

behavior/neurological

behavior/neurological phenotype ( J:219706 )

N • mice exhibit no ataxia and normal motor coordination on the rotor-rod test

abnormal motor learning ( J:219706 )

• severely impaired adaptation of the horizontal optokinetic response

• however, horizontal optokinetic response prior to training is normal