Phenotypes Associated with This Genotype

Genotype
MGI:5896450

• Allelic Composition: Otud5^tm1Vmd/Otud5^tm1Vmd; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:219495 )

• in anti-CD3 antibody-injected mice

immune system

immune system phenotype ( J:219495 )

N • regulatory T cells exhibit normal suppressive function and function in a T cell transfer model of colitis

N • mice do not exhibit any signs of autoimmunity

intestinal inflammation ( J:219495 )

• anti-CD3 antibody-injected mice exhibit more severe inflammation in the lamina propria of the small intestine and with increased epithelial cell proliferation and death compared with control mice

decreased thymocyte number ( J:219495 )

• 2- to 3-fold reduction in single positive thymocytes

• however, the number of naive and memory CD4+ T cells are normal

abnormal T-helper 17 cell differentiation ( J:219495 )

• CD4+ T cells stimulated with PMA and ionomycin exhibit more Th17 cell differentiation compared with control cells

• increased IL17+ CD4+ T cells among intraepithelial lymphocytes

• increased Th17 cells in the small intestine, spleen and lymph node following injection of anti-CD3 antibodies

• however, Th2 cell differentiation is normal

decreased regulatory T cell number ( J:219495 )

• in the periphery but not the thymus

increased circulating interleukin-17 level ( J:219495 )

• following injection of anti-CD3 antibodies

increased interleukin-17 secretion ( J:219495 )

• increased IL17A in CD8+ T cell from naive mice and regulatory T cells after TCR stimulation

• increased IL17F in Th17 cells derived with TGFbeta and IL6 that persists after secondary and tertiary TCR stimulation

increased interleukin-21 secretion ( J:219495 )

• in Th17 cells derived with TGFbeta and IL6

increased interleukin-9 secretion ( J:219495 )

• in Th17 cells derived with TGFbeta and IL6

homeostasis/metabolism

increased circulating interleukin-17 level ( J:219495 )

• following injection of anti-CD3 antibodies

increased susceptibility to xenobiotic induced morbidity/mortality ( J:219495 )

• in anti-CD3 antibody-injected mice

digestive/alimentary system

intestinal inflammation ( J:219495 )

• anti-CD3 antibody-injected mice exhibit more severe inflammation in the lamina propria of the small intestine and with increased epithelial cell proliferation and death compared with control mice

endocrine/exocrine glands

decreased thymocyte number ( J:219495 )

• 2- to 3-fold reduction in single positive thymocytes

• however, the number of naive and memory CD4+ T cells are normal

hematopoietic system

decreased thymocyte number ( J:219495 )

• 2- to 3-fold reduction in single positive thymocytes

• however, the number of naive and memory CD4+ T cells are normal

abnormal T-helper 17 cell differentiation ( J:219495 )

• CD4+ T cells stimulated with PMA and ionomycin exhibit more Th17 cell differentiation compared with control cells

• increased IL17+ CD4+ T cells among intraepithelial lymphocytes

• increased Th17 cells in the small intestine, spleen and lymph node following injection of anti-CD3 antibodies

• however, Th2 cell differentiation is normal

decreased regulatory T cell number ( J:219495 )

• in the periphery but not the thymus