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Phenotypes Associated with This Genotype
Genotype
MGI:5896360
Allelic
Composition		 Grhl1tm1Jane/Grhl1tm1Jane
Grhl3tm1Jane/Grhl3tm3.1Jane
Tg(KRT14-cre/ERT)20Efu/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl1tm1Jane mutation (1 available); any Grhl1 mutation (33 available)
Grhl3tm1Jane mutation (1 available); any Grhl3 mutation (53 available)
Grhl3tm3.1Jane mutation (1 available); any Grhl3 mutation (53 available)
Tg(KRT14-cre/ERT)20Efu mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:233531 )
• all die within 7 weeks of tamoxifen treatment

integument
abnormal corneocyte envelope morphology ( J:233531 )
• after tamoxifen treatment gross abnormalities and increased fragility are seen
impaired skin barrier function ( J:233531 )
• regression of skin barrier function after tamoxifen treatment
• dye penetration is variegated matching the pattern of cre mediated gene deletion
thick epidermis ( J:233531 )
• after tamoxifen treatment

homeostasis/metabolism
impaired skin barrier function ( J:233531 )
• regression of skin barrier function after tamoxifen treatment
• dye penetration is variegated matching the pattern of cre mediated gene deletion

cellular
abnormal corneocyte envelope morphology ( J:233531 )
• after tamoxifen treatment gross abnormalities and increased fragility are seen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory