Phenotypes Associated with This Genotype

Genotype
MGI:5888879

• Allelic Composition: Casc3^{tm1(KOMP)Vlcg}/Casc3^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:240595 )

• all homozygous mutant embryos die between E10.5 and E11.5

embryo

embryonic growth retardation ( J:240595 )

• at E10.5, homozygous mutant embryos exhibit developmental delay

abnormal embryo morphology ( J:240595 )

• at E10.5, homozygous mutant embryos appear dysmorphic relative to wild-type embryos

decreased embryo size ( J:240595 )

• at E10.5, homozygous mutant embryos are markedly smaller than wild-type embryos

growth/size/body

embryonic growth retardation ( J:240595 )

• at E10.5, homozygous mutant embryos exhibit developmental delay

decreased embryo size ( J:240595 )

• at E10.5, homozygous mutant embryos are markedly smaller than wild-type embryos