Phenotypes Associated with This Genotype

Genotype
MGI:5883624

• Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust
• Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Esr2^tm1.1Gust/Esr2^tm1.1Gust mouse ovaries display more atretic follicles and less corpora lutea than wild-type mice

reproductive system

reproductive system phenotype ( J:220968 )

♂N • males are fertile and exhibit normal ventral prostate morphology and histology with no detectable changes in proliferation or in androgen receptor or DACH-1 expression in the ventral prostate epithelium relative to wild-type controls

absent corpus luteum ( J:220968 )

♀ • at 7-8 months of age, mutant ovaries display absence of corpora lutea

absent mature ovarian follicles ( J:220968 )

♀ • no viable preovulatory follicles are observed due to a lack of late follicular maturation

increased secondary ovarian follicle number ( J:220968 )

♀ • at 7-8 months of age, many preantral follicles are observed

increased atretic ovarian follicle number ( J:220968 )

♀ • at 7-8 months of age, mutant ovaries display more atretic follicles than wild-type ovaries

♀ • however, no significant difference in the number of developing follicles is observed

abnormal tertiary ovarian follicle morphology ( J:220968 )

♀ • at 7-8 months of age, a few early antral follicles are observed and most late antral follicles are atretic

anovulation ( J:220968 )

♀ • females are anovulatory

female infertility ( J:220968 )

♀ • females are infertile

endocrine/exocrine glands

absent corpus luteum ( J:220968 )

♀ • at 7-8 months of age, mutant ovaries display absence of corpora lutea

absent mature ovarian follicles ( J:220968 )

♀ • no viable preovulatory follicles are observed due to a lack of late follicular maturation

increased secondary ovarian follicle number ( J:220968 )

♀ • at 7-8 months of age, many preantral follicles are observed

increased atretic ovarian follicle number ( J:220968 )

♀ • at 7-8 months of age, mutant ovaries display more atretic follicles than wild-type ovaries

♀ • however, no significant difference in the number of developing follicles is observed

abnormal tertiary ovarian follicle morphology ( J:220968 )

♀ • at 7-8 months of age, a few early antral follicles are observed and most late antral follicles are atretic