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Phenotypes Associated with This Genotype
Genotype
MGI:5883223
Allelic
Composition
Otogvbd/Otogvbd
Genetic
Background
involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otogvbd mutation (0 available); any Otog mutation (110 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• 2 of 20 mice at weaning age show abnormal Preyer reflex, with a further 10 becoming progressively unresponsive between 8 and 12 weeks of age, and all mice becoming unresponsive by 16 weeks
• when mice are placed on their backs, they stay supine without trying to rotate to an upright position
• after 2 weeks of age, more than 90% of mice have a one side tilted head and show impaired balance
• when held by the tail and dropped onto a soft surface, mutants fall on their back or their sides instead of landing on their feet like wild-type mice, indicating a saccular defect
• mutants are unable to swim or float properly, but remain submerged, completely disoriented, while turning under water
• after 2 weeks of age, more than 90% of mice have a one side tilted head and show impaired balance
• 10% of mice show a circulating behavior after P10 that persists into adulthood

nervous system
• stereocilia of the sensory hair cells are less numerous

hearing/vestibular/ear
• stereocilia of the sensory hair cells are less numerous
• older (> P100) mice exhibit detached cupula in the crista ampullaris
• however, otoconia are preserved and the cochlea is normal
• anomalies in the saccular macula
• only a few remnants of the otoconial membrane are present on saccular maculae
• however, the supporting cells at the base of the maculae are preserved
• numerous type I hair cells of the maculae have a shrunken nucleus

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive nonsyndromic deafness 18B DOID:0110474 OMIM:614945
J:234038


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory