Phenotypes for Gars1 Scn8a MGI:5882509 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gars1^Nmf249/Gars1⁺ Scn8a^m10J/Scn8a⁺
Genetic Background	involves: C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1^Nmf249 mutation (1 available); any Gars1 mutation (43 available)
Scn8a^m10J mutation (0 available); any Scn8a mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

skeletal muscle atrophy ( J:240096 )

• slightly more severe than the parental heterozygote

nervous system

abnormal neuromuscular synapse morphology ( J:240096 )

• decreased neuromuscular junction innervation compared with either parental heterozygotes

decreased nerve conduction velocity ( J:240096 )

• decreased relative to either parental heterozygote

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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