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Phenotypes Associated with This Genotype
Genotype
MGI:5882411
Allelic
Composition		 Cdkn2atm1Cjs/Cdkn2a+
Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-Hgf,-EGFP)24Tcre/0
Genetic
Background		 involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (5 available); any Cdkn2a mutation (59 available)
Tg(CKMM-tTA)A3Rhvh mutation (2 available)
Tg(tetO-Hgf,-EGFP)24Tcre mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
increased rhabdomyosarcoma incidence ( J:237183 )
• mice develop multi-step embryonal rhabdomyosarcoma with a latency of 6 months
• majority of tumors lose the wild-type allele

neoplasm
increased rhabdomyosarcoma incidence ( J:237183 )
• mice develop multi-step embryonal rhabdomyosarcoma with a latency of 6 months
• majority of tumors lose the wild-type allele

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory