embryo
• defective vascular development in yolk sacs
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mortality/aging
• fewer than the expected numbers of mice are recovered
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cardiovascular system
• defective vascular development in embryos and yolk sacs
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• implanted melanoma cells that develop into tumors show decreased vascular density compared to controls
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• defective vascular development in yolk sacs
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• about 35% of adult mice show hemorrhages in the brain, lungs, and other tissues
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• microvascular endothelial cells (MECs) show decreased capability to form capillary tubes
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• adult mice show increased vascular permeability
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neoplasm
• implanted melanoma cells that develop into tumors show decreased vascular density compared to controls
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• tumor growth of both B16F10 and B16F0 melanoma cells is inhibited compared to growth in wild-type mice
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respiratory system