Phenotypes Associated with This Genotype

Genotype
MGI:5881944

• Allelic Composition: Rpl13a^tm1.1Jesc/Rpl13a^tm1.1Jesc
• Genetic Background: FVB.129S5(Cg)-Rpl13a^tm1.1Jesc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal oxidative phosphorylation ( J:237822 )

• increased mitochondrial proton leak in pancreatic islets under stimulatory (20 mM glucose), but not basal, conditions

abnormal redox activity ( J:237822 )

• MEFs have lower levels of cellular superoxide and hydrogen peroxide

• following hydrogen peroxide exposure, MEFs exhibit a diminished ability to amplify ROS

• intact pancreatic islets have a 60% decrease in basal superoxide content as compared to control

• dispersed islets have lower ROS under both basal and stimulatory conditions as compared to control

endocrine/exocrine glands

increased insulin secretion ( J:237822 )

• pancreatic islets have a 51% increase in glucose-stimulated insulin secretion

homeostasis/metabolism

increased insulin secretion ( J:237822 )

• pancreatic islets have a 51% increase in glucose-stimulated insulin secretion

abnormal circulating glucose level ( J:237822 )

• mice treated with STZ are hyperglycemic but to a lower level than STZ-treated controls

increased oxygen consumption ( J:237822 )

• increase in basal and maximal respiration at 20 mM glucose, however oxygen consumption rate is similar to control under basal conditions

improved glucose tolerance ( J:237822 )

• enhanced glucose tolerance with lower peak glucose excursion and decreased area under the curve (AUC)

• however, response to the insulin tolerance test is similar to control