Phenotypes Associated with This Genotype

Genotype
MGI:5829825

• Allelic Composition: Tg(Gfap-gp120)10Lms/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

astrocytosis ( J:146427 )

• widespread reactive astrocytosis

microgliosis ( J:146427 )

• mice exhibit increased number of F4/80+ microglial cells that display increased branching and cytoplasmic distension, suggesting microglial activation

abnormal dendrite morphology ( J:146427 )

• extensive vacuolizations of dendrites

abnormal synapse morphology ( J:146427 )

• decrease in synpato-dendritic complexity

neuron degeneration ( J:146427 )

• loss of large pyramidal neurons

immune system

microgliosis ( J:146427 )

• mice exhibit increased number of F4/80+ microglial cells that display increased branching and cytoplasmic distension, suggesting microglial activation

hematopoietic system

microgliosis ( J:146427 )

• mice exhibit increased number of F4/80+ microglial cells that display increased branching and cytoplasmic distension, suggesting microglial activation

cellular

astrocytosis ( J:146427 )

• widespread reactive astrocytosis

microgliosis ( J:146427 )

• mice exhibit increased number of F4/80+ microglial cells that display increased branching and cytoplasmic distension, suggesting microglial activation