Phenotypes Associated with This Genotype

Genotype
MGI:5829816

• Allelic Composition: Rr39^em1Ched/Rr39^em1Ched
• Genetic Background: C57BL/6-Rr39^em1Ched

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased Ly6C low monocyte number ( J:239509 )

• substantial decrease in Ly6^low peripheral blood monocytes

immune system

immune system phenotype ( J:239509 )

N • response to high dose LPS challenge is similar to controls

decreased Ly6C low monocyte number ( J:239509 )

• substantial decrease in Ly6^low peripheral blood monocytes

neoplasm

increased tumor growth/size ( J:239509 )

• following injection of B16F10 melanoma cells, mice exhibit a higher tumor burden than wild-type