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Phenotypes Associated with This Genotype
Genotype
MGI:5829784
Allelic
Composition		 Tg(Prnp-MAPT)#Lgn/0
Genetic
Background		 involves: C57BL/6 * FVB/N
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No mouse lines available in IMSR.
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
astrocytosis ( J:230252 )
• astrogliosis in the dentate gyrus
• however, mice do not show tau accumulation in hippocampal mossy fibers, normal long term potentiation and synaptic plasticity in the hippocampus, and normal pattern separation memory in an object-context discrimination test

cellular
astrocytosis ( J:230252 )
• astrogliosis in the dentate gyrus
• however, mice do not show tau accumulation in hippocampal mossy fibers, normal long term potentiation and synaptic plasticity in the hippocampus, and normal pattern separation memory in an object-context discrimination test

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory