Phenotypes Associated with This Genotype

Genotype
MGI:5829783

• Allelic Composition: Tg(Prnp-MAPT*K274Q*K281Q)1Lgn/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

astrocytosis ( J:230252 )

• astrogliosis in the dentate gyrus

tau protein deposits ( J:230252 )

• mice show pathological tau accumulation (higher MC1 immunoreactive tau) in hippocampal mossy fibers

impaired synaptic plasticity ( J:230252 )

• synaptic plasticity in hippocampus is impaired

reduced long-term potentiation ( J:230252 )

• after theta-burst stimulation of the perforant pathway to dentate granule cell synapses, potentiation significantly declines in dentate gyrus molecular layer brain slices by 60 min after LTP induction

cellular

astrocytosis ( J:230252 )

• astrogliosis in the dentate gyrus