Phenotypes Associated with This Genotype

Genotype
MGI:5829205

• Allelic Composition: Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho; Tg(Ins2-Akt1*)3Mbb/0
• Genetic Background: B6.Cg-Rps6kb1^tm1Gtho Tg(Ins2-Akt1*)3Mbb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Beta cell and islet size in Tg(Ins2-Akt1*)3Mbb/0, Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho, and double mutant mice

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:144599 )

• increase in size of pancreatic beta cells

growth/size/body

decreased body weight ( J:144599 )

homeostasis/metabolism

decreased circulating glucose level ( J:144599 )

• decrease in fed and fasting glucose levels

• control of glycemia after injection of glucose is not affected

decreased circulating insulin level ( J:144599 )

• 35% reduction of plasma insulin levels

increased insulin sensitivity ( J:144599 )

• mice are more insulin sensitive than single Tg(Ins2-Akt1*)3Mbb