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Phenotypes Associated with This Genotype
Genotype
MGI:5829200
Allelic
Composition
Tg(Ins2-Akt1*)3Mbb/0
Genetic
Background
B6.Cg-Tg(Ins2-Akt1*)3Mbb
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phenotype observed in females
phenotype observed in males
N normal phenotype

Tg(Ins2-Akt1*)3Mbb/0 mice develop insulinomas

endocrine/exocrine glands
• 70% of mice show dysplastic islets with disorganized cells, irregular in shape and size
• pancreatic beta cells are 5 times larger than wild-type cells
• beta cells have prominent nuclei with large nucleoli and are surrounded by dilated and asymmetric vessels
• increase in beta cell mass by 3.5-fold
• islet hypertrophy, as defined by large beta cells which maintain an organized structure with well-defined margins
• mice develop pancreatic islet tumors in older age
• 30% penetrance of insulinomas after 10 months of age
• insulinomas are classified as adenomas with rounded and encapsulated edges or multinodular adenomas with partial loss of the fibrous capsule
• 4 of 19 tumor cases are invasive carcinomas
• one case of lung metastasis is seen
• in the pancreatic carcinoma and lung metastasis, Brd-U positive malignant tumor cells are negative for the transgene and insulin expression and negative for neuroendocrine markers
• peripheral or infiltrating fibrosis is commonly seen in islets

homeostasis/metabolism
• hypoglycemia in the fed and fasted state
• 2.6-fold higher insulin levels at 3 months of age
• control of glycemia after injection of glucose is improved

mortality/aging
• lethality is increased after 1 year of age; death is preceded by hypoglycemia

neoplasm
• mice develop pancreatic islet tumors in older age
• 30% penetrance of insulinomas after 10 months of age
• insulinomas are classified as adenomas with rounded and encapsulated edges or multinodular adenomas with partial loss of the fibrous capsule
• 4 of 19 tumor cases are invasive carcinomas
• one case of lung metastasis is seen
• in the pancreatic carcinoma and lung metastasis, Brd-U positive malignant tumor cells are negative for the transgene and insulin expression and negative for neuroendocrine markers


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory