Phenotypes Associated with This Genotype

Genotype
MGI:5829194

• Allelic Composition: Tg(Ins2-Akt1*)3Mbb/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:72216 )

• 8-fold increase in islet mass

• islets have a reduced quantity of insulin when expressed per islet, but a slightly increased amount when normalized to cell number

• however, no changes in size of the pancreas

abnormal pancreatic beta cell morphology ( J:72216 )

• increase in the size of individual beta cells

• however, both alpha and delta cells appear normal

increased pancreatic beta cell mass ( J:72216 )

decreased pancreatic beta cell number ( J:72216 )

• decrease in the number of beta cells per islet

increased pancreatic islet number ( J:72216 )

enlarged pancreatic islets ( J:72216 )

abnormal pancreatic beta cell physiology ( J:72216 )

• 4.5-fold increase in pancreatic insulin

• however, glucagon levels are unchanged

• basal apoptosis is elevated about 2-fold in in beta cells

abnormal insulin secretion ( J:72216 )

• pancreas shows increased insulin secretion in response to elevations in glucose applied over time, however, when data are corrected for the increase in beta-cell mass, there is impaired secretion in response to glucose

homeostasis/metabolism

abnormal insulin secretion ( J:72216 )

• pancreas shows increased insulin secretion in response to elevations in glucose applied over time, however, when data are corrected for the increase in beta-cell mass, there is impaired secretion in response to glucose

decreased circulating glucose level ( J:72216 )

• mice exhibit mild fasting and fed hypoglycemia

increased circulating insulin level ( J:72216 )

improved glucose tolerance ( J:72216 )

• mice show a blunted excursion of blood glucose following a glucose load

• however, mice show a normal hypoglycemic response upon insulin administration and normal insulin responsiveness in the insulin tolerance test

decreased susceptibility to non-insulin-dependent diabetes ( J:72216 )

• mice are resistant to developing streptozotocin-induced diabetes mellitus