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Phenotypes Associated with This Genotype
Genotype
MGI:5828495
Allelic
Composition		 Tg(Camk2a-tTA)1Mmay/0
Tg(PDGFB-APPSwInd)J9Lms/0
Tg(tetO-MAPT*A152T)L1Lms/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(PDGFB-APPSwInd)J9Lms mutation (0 available)
Tg(tetO-MAPT*A152T)L1Lms mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, incomplete penetrance ( J:233816 )
• fewer than the expected numbers (8 of 282) of mice were obtained
• surviving mice do not die before adulthood, with one dying at 7 months, another at 10 months and the remaining being alive at 11-17 months

nervous system
abnormal brain wave pattern ( J:233816 )
• EEG recordings show more abundant epileptic spikes than in controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory