Phenotypes Associated with This Genotype

Genotype
MGI:5828129

• Allelic Composition: Bhlha15^{tm3(cre/ERT2)Skz}/Bhlha15^{tm3(cre/ERT2)Skz}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal autophagy ( J:239144 )

• acinar cells have high levels of autophagic vacuoles

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:239144 )

• acinar cells lack an apical-basal polarity

• nuclei and rough endoplasmic reticulum fail to accumulate at the basal pole and zymogen granules fail to cluster at the apical pole

• acini lumens are highly dilated with reduced secretion of zymogens into ductal system

• acini cells are small and lack a cortical and terminal actin web

• acinar cells lack connexin32-containing gap junctions

• acinar cells have high levels of autophagic vacuole

abnormal pancreatic acinar cell zymogen granule morphology ( J:239144 )

• diameters of zymogen granules are decreased in size

abnormal pancreatic acinar cell physiology ( J:239144 )

• acini lumens are highly dilated with reduced secretion of zymogens into ductal system

decreased pancreatic amylase secretion ( J:239144 )

• acinar cells are unresponsive to cholecytokinin induction of exocytosis as measured by amylase secretion

endocrine/exocrine glands

abnormal pancreatic acinar cell morphology ( J:239144 )

• acinar cells lack an apical-basal polarity

• nuclei and rough endoplasmic reticulum fail to accumulate at the basal pole and zymogen granules fail to cluster at the apical pole

• acini lumens are highly dilated with reduced secretion of zymogens into ductal system

• acini cells are small and lack a cortical and terminal actin web

• acinar cells lack connexin32-containing gap junctions

• acinar cells have high levels of autophagic vacuole

abnormal pancreatic acinar cell zymogen granule morphology ( J:239144 )

• diameters of zymogen granules are decreased in size

abnormal pancreatic acinar cell physiology ( J:239144 )

• acini lumens are highly dilated with reduced secretion of zymogens into ductal system

decreased pancreatic amylase secretion ( J:239144 )

• acinar cells are unresponsive to cholecytokinin induction of exocytosis as measured by amylase secretion

homeostasis/metabolism

abnormal autophagy ( J:239144 )

• acinar cells have high levels of autophagic vacuoles