Phenotypes Associated with This Genotype

Genotype
MGI:5827750

• Allelic Composition: Tg(MMTV-KRAS*G12V)3025Mrl/0
• Genetic Background: involves: C57BL/6 * FVB * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

retina degeneration ( J:77272 )

• moderate retinal atrophy characterized by loss of the outer layers (rods and cones, outer nuclear layer, and outer plexiform layer)

neoplasm

increased mammary adenocarcinoma incidence ( J:77272 )

• males and females develop mammary tumors

• tumor latency is inversely correlated with generation number, with tumor latency for F1 females being 8 months and 5 months for F3 females

• mice develop multiple, distinct tumors, with an average tumor burden of 5 tumors per mouse

• tumors are adenocarcinomas

• treatment with the FPTase inhibitor L-744,832 results in inhibition of tumor growth

increased metastatic potential ( J:77272 )

• metastases to the lung are occasionally seen

integument

increased mammary adenocarcinoma incidence ( J:77272 )

• males and females develop mammary tumors

• tumor latency is inversely correlated with generation number, with tumor latency for F1 females being 8 months and 5 months for F3 females

• mice develop multiple, distinct tumors, with an average tumor burden of 5 tumors per mouse

• tumors are adenocarcinomas

• treatment with the FPTase inhibitor L-744,832 results in inhibition of tumor growth

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:77272 )

• males and females develop mammary tumors

• tumor latency is inversely correlated with generation number, with tumor latency for F1 females being 8 months and 5 months for F3 females

• mice develop multiple, distinct tumors, with an average tumor burden of 5 tumors per mouse

• tumors are adenocarcinomas

• treatment with the FPTase inhibitor L-744,832 results in inhibition of tumor growth