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Phenotypes Associated with This Genotype
Genotype
MGI:5824893
Allelic
Composition		 Oprk1tm2.1Kff/Oprk1tm2.1Kff
Tg(Fev-cre)1Esd/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprk1tm2.1Kff mutation (1 available); any Oprk1 mutation (28 available)
Tg(Fev-cre)1Esd mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal associative learning ( J:226396 )
• resistant to agonist U50,488-induced conditioned place aversion (CPA), however, like controls, evoked dopamine response is inhibited in response to agonist

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory