Phenotypes Associated with This Genotype

Genotype
MGI:5824825

• Allelic Composition: Cyp26b1^tm1Hmd/Cyp26b1^tm1Hmd; Tg(Prox1-EGFP)KY221Gsat/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphatic vessel morphology ( J:206581 )

• mice exhibit hyperplastic, blood-filled deep and superficial lymphatics due to defects in lympho-venous valve patterning compared with wild-type mice

• jugular lymph sacs are enlarged compared to in wild-type mice

abnormal lymphatic vessel endothelial cell morphology ( J:206581 )

• expanded and ectopic distribution of PROX1+ and LYVE1 lymphatic endothelial cell progenitor (LEC) cells to the ventral and medial aspects of the cardinal vein at E11.5

• mice exhibit an increase in the pool of venous LEC progenitors due to increased proliferation compared with wild-type mice

cardiovascular system

cardiovascular system phenotype ( J:206581 )

N • overall morphology and size of veins are normal

hemorrhage ( J:206581 )

• hemorrhage in the region of the developing jugular lymph sacs at E13.5

homeostasis/metabolism

skin edema ( J:206581 )

• pronounced edema at E14.5 and E16.5

integument

skin edema ( J:206581 )

• pronounced edema at E14.5 and E16.5