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Phenotypes Associated with This Genotype
Genotype
MGI:5824730
Allelic
Composition
Dlg3tm1Grnt/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg3tm1Grnt mutation (0 available); any Dlg3 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• brain mass is reduced
• total neocortical area is reduced
• reduction in the total numbers of thalamocortical axons innervating the somatosensory cortex
• however, segregation of barrels is unaffected
• area of posteromedial barrel subfield is reduced
• combined area of all thalamocortical axon patches in the barrel cortex is reduced indicating a reduction in thalamocortical innervation of barrel cortex
• P8-10 mice show a reduction in connectivity of individual thalamocortical axons onto L4 neurons despite normal NMDA receptor function after the critical period
• reduction in neurofilament medium polypeptide-positive axons in barrel cortex in P6-7 mice
• decrease in the number of thalamocortical axons
• thalamocortical synapses transiently show altered NMDA receptor function
• however, after the critical period thalamocortical synapses function normally
• reduction in peak excitatory postsynaptic current (EPSC) amplitude
• however, no differences are seen in minimal stimulation EPSC amplitude
• NMDA excitatory postsynaptic currents (EPSCs) show faster decay kinetics during the critical period for thalamocortical plasticity
• treatment with ifenprodil, a GluN2B-specific antagonist, has no effect on NMDA EPSCs


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory