Phenotypes Associated with This Genotype

Genotype
MGI:5824708

• Allelic Composition: Cd6^tm1Linf/Cd6^tm1Linf
• Genetic Background: D1.Cg-Cd6^tm1Linf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B-1 B cell number ( J:238478 )

• 1.2- and 1.7- fold compensatory reduction in the frequency and absolute numbers in the peritoneal cavity

decreased B-1a cell number ( J:238478 )

• 4- and 2.5-fold reduction in the frequency and absolute numbers in the liver

• 1.5-fold in the frequency in peripheral blood

• 2- and 2.5-fold decrease in the frequency and absolute numbers in the spleen

increased B-1a cell number ( J:238478 )

• 1.8-fold increase in the frequency in the peritoneal cavity

increased B-1b cell number ( J:238478 )

• 1.7- and 2.9-fold increase in the frequency and absolute numbers in the liver

• 1.4-fold in the frequency in peripheral blood

abnormal B cell physiology ( J:238478 )

• impaired B1a cell self-renewal

decreased B cell proliferation ( J:238478 )

• of splenic B1a cells by 1.5-fold

• however, peritoneal bone marrow B1a cell proliferation is normal as is apoptosis rates in the spleen

decreased IgM level ( J:238478 )

• 1.9-fold

• however, IgG serum levels are normal

decreased interleukin-6 secretion ( J:238478 )

• following ischemia and reperfusion of the intestine

homeostasis/metabolism

decreased susceptibility to injury ( J:238478 )

• following ischemia and reperfusion of the intestine, mice exhibit increased epithelial cell layer integrity and lower tissue damage and IL6 levels in jejunum tissue compared with wild-type mice

• however, reconstitution of IgM levels restores increased local inflammation following ischemia and reperfusion of the intestine

hematopoietic system

decreased B-1 B cell number ( J:238478 )

• 1.2- and 1.7- fold compensatory reduction in the frequency and absolute numbers in the peritoneal cavity

decreased B-1a cell number ( J:238478 )

• 4- and 2.5-fold reduction in the frequency and absolute numbers in the liver

• 1.5-fold in the frequency in peripheral blood

• 2- and 2.5-fold decrease in the frequency and absolute numbers in the spleen

increased B-1a cell number ( J:238478 )

• 1.8-fold increase in the frequency in the peritoneal cavity

increased B-1b cell number ( J:238478 )

• 1.7- and 2.9-fold increase in the frequency and absolute numbers in the liver

• 1.4-fold in the frequency in peripheral blood

abnormal B cell physiology ( J:238478 )

• impaired B1a cell self-renewal

decreased B cell proliferation ( J:238478 )

• of splenic B1a cells by 1.5-fold

• however, peritoneal bone marrow B1a cell proliferation is normal as is apoptosis rates in the spleen

decreased IgM level ( J:238478 )

• 1.9-fold

• however, IgG serum levels are normal

cellular

decreased B cell proliferation ( J:238478 )

• of splenic B1a cells by 1.5-fold

• however, peritoneal bone marrow B1a cell proliferation is normal as is apoptosis rates in the spleen