Phenotypes Associated with This Genotype

Genotype
MGI:5824343

• Allelic Composition: Tmod4^{tm1(KOMP)Wtsi}/Tmod4^{tm1(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0400_4_E05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:236433 )

• mice are viable, fertile, and exhibit no overt myopathy and normal thin filament lengths, myofibril organization, and skeletal muscle contractile function due to compensatory upregulation of Tmod1 in neonatal skeletal muscle, along with an Lmod isoform switch wherein Lmod3 is downregulated and Lmod2 is upregulated