Phenotypes Associated with This Genotype

Genotype
MGI:5824124

• Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi; Tg(Camk2a-cre)T29-1Stl/0
• Genetic Background: involves: BALB/c * C57BL * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal social investigation ( J:217829 )

• in the three-chamber test, mice show impaired preference for sniffing the social target and for social novelty

• however, mice do not exhibit repetitive behaviors, motor defects, or anxiety-like behaviors

• treatment with rapamycin does not rescue social deficits

abnormal response to social novelty ( J:217829 )

• during dyadic encounters, mice spend less time sniffing stimulus mice than control littermates

homeostasis/metabolism

impaired autophagy ( J:217829 )

• mice exhibit occasional p62/ubiquitin-positive inclusions in pyramidal neurons at P20 and prominent p62/ubiquitin-positive aggregates in layer II-III and layer V-VI pyramidal neurons at P30, indicating loss of autophagy between P20 and P30 in cortical pyramidal neurons

cellular

impaired autophagy ( J:217829 )

• mice exhibit occasional p62/ubiquitin-positive inclusions in pyramidal neurons at P20 and prominent p62/ubiquitin-positive aggregates in layer II-III and layer V-VI pyramidal neurons at P30, indicating loss of autophagy between P20 and P30 in cortical pyramidal neurons

nervous system

abnormal dendritic spine morphology ( J:217829 )

• by P29-P30, but not at P19-P20, basal dendrites from layer V A1/S2 pyramidal neurons exhibit more spines than controls, indicating impaired spine pruning, with only 3% of spines pruned between P21 and P29

• treatment with rapamycin does not rescue spine pruning