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Phenotypes Associated with This Genotype
Genotype
MGI:5824122
Allelic
Composition		 Tsc2tm1Djk/Tsc2+
Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Tsc2tm1Djk mutation (1 available); any Tsc2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal autophagosome formation ( J:217829 )
• failure of autophagosome induction in neurons
• rapamycin treatment normalizes autophagosome formation in neurons

homeostasis/metabolism
abnormal autophagosome formation ( J:217829 )
• failure of autophagosome induction in neurons
• rapamycin treatment normalizes autophagosome formation in neurons

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory