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Phenotypes Associated with This Genotype
Genotype
MGI:5824009
Allelic
Composition		 Piezo1tm1a(KOMP)Wtsi/Piezo1+
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Cell Lines EPD0500_5_F12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piezo1tm1a(KOMP)Wtsi mutation (1 available); any Piezo1 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular endothelial cell morphology ( J:217082 )
• at 6-8 weeks of age, cerebral arteries show a striking misorganization of CD31-positive endothelial cells with a directionless cobblestone-like appearance, unlike the linear appearance in the direction of flow observed wild-type controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory