Analysis Tools
homeostasis/metabolism
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• on a chow diet, mice show no differences in glucose or insulin tolerance relative to wild-type controls
• HFD-fed mice show normal rates of oxygen consumption, carbon dioxide production, respiratory exchange ratios, and energy expenditure relative to similarly fed wild-type controls
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• HFD-fed mice show robust insulin secretion at 30 min after glucose injection
• however, no differences are observed in a glucose tolerance test on a HFD
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• aged mice (>10 months of age) fed a HFD later in life show lowered fasting blood glucose levels relative to similarly treated wild-type controls
• however, mice fed a chow diet or HFD at weaning exhibit normal fasting blood glucose levels relative to similarly fed wild-type controls
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• on a chow diet or HFD, mice show significantly lower fasting insulin levels relative to similarly fed wild-type controls
• aged mice (>10 months of age) fed a HFD later in life show lowered fasting insulin levels relative to similarly treated wild-type controls
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• HFD-fed mice exhibit reduced gluconeogenic gene (glucose-6-phosphatase, G6pc) expression in liver
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• aged mice (>10 months of age) fed a HFD later in life show improved glucose tolerance relative to similarly treated wild-type controls
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• on a chow diet or HFD, mice show a significantly lower insulin resistance index (HOMA-IR) relative to similarly fed wild-type controls
• HFD-fed mice show a significantly greater rate of insulin-stimulated glucose clearance in peripheral tissues than similarly fed wild-type controls
• aged mice (>10 months of age) fed a HFD later in life show reduced insulin resistance and improved insulin tolerance relative to similarly treated wild-type controls
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• HFD-fed mice exhibit reduced hepatic triglyceride content, but not cholesterol levels, relative to similarly fed wild-type controls
• aged mice (>10 months of age) fed a HFD later in life show decreased expression of genes involved in hepatic triglyceride synthesis relative to similarly treated wild-type controls
• however, triglyceride levels in serum and skeletal muscle are normal
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liver/biliary system
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• HFD-fed mice exhibit reduced hepatic triglyceride content, but not cholesterol levels, relative to similarly fed wild-type controls
• aged mice (>10 months of age) fed a HFD later in life show decreased expression of genes involved in hepatic triglyceride synthesis relative to similarly treated wild-type controls
• however, triglyceride levels in serum and skeletal muscle are normal
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• HFD-fed mice exhibit reduced hepatic steatosis relative to similarly fed wild-type controls
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behavior/neurological
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• HFD-fed mice exhibit a very modest reduction in food intake during the dark cycle relative to similarly fed wild-type controls
• however, no significant changes in average body weight or adiposity are observed over time
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endocrine/exocrine glands
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• HFD-fed mice show robust insulin secretion at 30 min after glucose injection
• however, no differences are observed in a glucose tolerance test on a HFD
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growth/size/body
| N |
• mice fed a chow diet or a high-fat diet (HFD) exhibit normal body weight and body composition (fat and lean mass) relative to similarly fed wild-type controls
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adipose tissue
| N |
• HFD-fed mice exhibit no alterations in adipose tissue inflammation and fibrosis relative to similarly fed wild-type controls
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