Phenotypes Associated with This Genotype

Genotype
MGI:5818970

• Allelic Composition: Cd276^tm1Lpc/Cd276^tm1Lpc
• Genetic Background: D1J.129-Cd276^tm1Lpc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cd276^tm1Lpc/Cd276^tm1Lpc mice are resistant to collagen-induced arthritis

immune system

abnormal T-helper 1 physiology ( J:237700 )

• collagen II specific T cell proliferation and cytokine (IFN-gamma, IL-2, IL-6, TNF, and IL-17) production are reduced in splenocytes isolated from mice with collagen-induced arthritis, suggesting that Th1, Th17, and B cell responses are suppressed

abnormal T-helper 17 cell physiology ( J:237700 )

• collagen II specific T cell proliferation and cytokine (IFN-gamma, IL-2, IL-6, TNF, and IL-17) production are reduced in splenocytes isolated from mice with collagen-induced arthritis, suggesting that Th1, Th17, and B cell responses are suppressed

decreased susceptibility to induced arthritis ( J:237700 )

• mice exhibit decreased severity of collagen-induced arthritis, showing a later onset, an attenuated severity of arthritis, decreased severity in joint swelling, and lower levels of collagen II-specific IgG

• collagen II specific T cell proliferation and cytokine (IFN-gamma, IL-2, IL-6, TNF, and IL-17) production are reduced in splenocytes isolated from mice with collagen-induced arthritis, suggesting that Th1, Th17, and B cell responses are suppressed

hematopoietic system

abnormal T-helper 1 physiology ( J:237700 )

• collagen II specific T cell proliferation and cytokine (IFN-gamma, IL-2, IL-6, TNF, and IL-17) production are reduced in splenocytes isolated from mice with collagen-induced arthritis, suggesting that Th1, Th17, and B cell responses are suppressed

abnormal T-helper 17 cell physiology ( J:237700 )

• collagen II specific T cell proliferation and cytokine (IFN-gamma, IL-2, IL-6, TNF, and IL-17) production are reduced in splenocytes isolated from mice with collagen-induced arthritis, suggesting that Th1, Th17, and B cell responses are suppressed

skeleton

decreased susceptibility to induced arthritis ( J:237700 )

• mice exhibit decreased severity of collagen-induced arthritis, showing a later onset, an attenuated severity of arthritis, decreased severity in joint swelling, and lower levels of collagen II-specific IgG

• collagen II specific T cell proliferation and cytokine (IFN-gamma, IL-2, IL-6, TNF, and IL-17) production are reduced in splenocytes isolated from mice with collagen-induced arthritis, suggesting that Th1, Th17, and B cell responses are suppressed