Phenotypes Associated with This Genotype

Genotype
MGI:5818967

• Allelic Composition: Cd276^tm1Lpc/Cd276^tm1Lpc
• Genetic Background: B6.129-Cd276^tm1Lpc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enhanced airway allergic responses in Cd276^tm1Lpc/Cd276^tm1Lpc mice

immune system

abnormal T-helper 1 physiology ( J:237700 )

• myelin-specific T cell response is reduced in response to MOG 33-35 peptide, with draining lymph nodes producing less IFN-gamma, IL-12, and IL-17, and generating a decreased proportion of IFN-gamma producing cells under Th1 polarizing conditions

abnormal T-helper 2 physiology ( J:237700 )

• mice show enhanced Th2-mediated allergic responses in the airway

• splenocytes from OVA-immunized mice re-challenged with OVA protein in vitro exhibit increased proliferation compared to wild-type cells

• when stimulated with OVA protein under Th2 polarizing conditions, splenocytes induce a larger proportion of IL-4 producing cells than from wild-type cells

increased susceptibility to type I hypersensitivity reaction ( J:237700 )

• mice immunized with injection of OVA-aluminum and challenged with aerosolized OVA protein exhibit higher total bronchoalveolar lavage fluid (BALF) cell counts, mainly in eosinophils, increased inflammation and mucus production, increase in IL-5 and IL-13 production in BALF, and an increase in OVA-specific IgE, indicating enhanced Th2-mediated allergic responses in the airway

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:237700 )

• mice are more resistant to experimental autoimmune encephalitis, showing attenuated symptoms during the course of disease development and partial recovery from symptoms even though disease incidence is 100%

• mice show fewer inflammatory cells in the proximal spinal cord

hematopoietic system

abnormal T-helper 1 physiology ( J:237700 )

• myelin-specific T cell response is reduced in response to MOG 33-35 peptide, with draining lymph nodes producing less IFN-gamma, IL-12, and IL-17, and generating a decreased proportion of IFN-gamma producing cells under Th1 polarizing conditions

abnormal T-helper 2 physiology ( J:237700 )

• mice show enhanced Th2-mediated allergic responses in the airway

• splenocytes from OVA-immunized mice re-challenged with OVA protein in vitro exhibit increased proliferation compared to wild-type cells

• when stimulated with OVA protein under Th2 polarizing conditions, splenocytes induce a larger proportion of IL-4 producing cells than from wild-type cells