Phenotypes Associated with This Genotype

Genotype
MGI:5817018

• Allelic Composition: Prdx6^tm2Abf/Prdx6^tm2Abf
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal phospholipid level ( J:237406 )

respiratory system

abnormal surfactant physiology ( J:237406 )

• increase in levels of total phospholipid, disaturated phosphatidylcholine (DSPC), and phosphatidylcholine (PC) in lung tissue, lung lavage fluid and lamellar bodies

• degradation of depalmitoylphosphatidylcholine (DPPC) in the lungs is decreased as compared to wild-type