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Phenotypes Associated with This Genotype
Genotype
MGI:5816495
Allelic
Composition
Fgf10tm1Wss/Fgf10+
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5
• branching of the lateral nasal glands is reduced at E17.5
• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced
• sublingual gland weight is decreased in 7-10-week old mice
• sublingual glands exhibit smaller glandular lobes in 7-10-week old mice
• however, glands show no morphological differences in histology
• mice show a delay in submandibular gland development
• E12.5 explant culture of submandibular glands show smaller epithelial prebud-like invaginations of the epithelium and this delay in development continues with reduced branching
• at E14.5, the epithelium fails to invade the most aboral part of the mesenchymal capsule in culture
• the epithelium of the mesenchymal capsule of the submandibular gland is less developed at E14.5, with fewer branches, larger epithelial buds and more extensive areas of mesenchyme not invaded by the epithelium
• submandibular gland and sublingual gland weight is decreased in 7-10-week old mice
• submandibular glands exhibit smaller glandular lobes in 7-10-week old mice
• however, glands show no morphological differences in histology
• the overall size of salivary gland lobes appears smaller and weight is reduced at P14
• males have larger glands compared to females
• mice show a reduction in saliva flow from both the submandibular gland and parotid gland
• mice show a reduction in the salivary pellicle on the tongue; mice treated with HCl to remove the mucus from the oral surface show complete removal of mucus unlike wild-type mice that show sheets of mucus remaining

behavior/neurological

craniofacial
• mice exhibit less enamel than controls and teeth of many mice show severe tooth wear, with almost complete loss of the cusp pattern in the most severe cases, due to reduced saliva
• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5
• branching of the lateral nasal glands is reduced at E17.5
• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

digestive/alimentary system
• sublingual gland weight is decreased in 7-10-week old mice
• sublingual glands exhibit smaller glandular lobes in 7-10-week old mice
• however, glands show no morphological differences in histology
• mice show a delay in submandibular gland development
• E12.5 explant culture of submandibular glands show smaller epithelial prebud-like invaginations of the epithelium and this delay in development continues with reduced branching
• at E14.5, the epithelium fails to invade the most aboral part of the mesenchymal capsule in culture
• the epithelium of the mesenchymal capsule of the submandibular gland is less developed at E14.5, with fewer branches, larger epithelial buds and more extensive areas of mesenchyme not invaded by the epithelium
• submandibular gland and sublingual gland weight is decreased in 7-10-week old mice
• submandibular glands exhibit smaller glandular lobes in 7-10-week old mice
• however, glands show no morphological differences in histology
• the overall size of salivary gland lobes appears smaller and weight is reduced at P14
• males have larger glands compared to females
• mice show a reduction in saliva flow from both the submandibular gland and parotid gland
• mice show a reduction in the salivary pellicle on the tongue; mice treated with HCl to remove the mucus from the oral surface show complete removal of mucus unlike wild-type mice that show sheets of mucus remaining

growth/size/body
• mice exhibit less enamel than controls and teeth of many mice show severe tooth wear, with almost complete loss of the cusp pattern in the most severe cases, due to reduced saliva
• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5
• branching of the lateral nasal glands is reduced at E17.5
• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

homeostasis/metabolism
• mice show a reduction in saliva flow from both the submandibular gland and parotid gland
• mice show a reduction in the salivary pellicle on the tongue; mice treated with HCl to remove the mucus from the oral surface show complete removal of mucus unlike wild-type mice that show sheets of mucus remaining

respiratory system
• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5
• branching of the lateral nasal glands is reduced at E17.5
• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

skeleton
• mice exhibit less enamel than controls and teeth of many mice show severe tooth wear, with almost complete loss of the cusp pattern in the most severe cases, due to reduced saliva

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
LADD syndrome DOID:0050331 OMIM:149730
J:237227


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory